Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
I'm gonna start with saying hi as i am a new member and this is my first build and a little introduction about why i build that way. I didn't make a full guide because i believe every player has different playing style.
I've seen so many Vayne players that build her differently. First of all, as she already has burst damage Doran's Blade is a wrong chice Doran's Shield works better on her as first item.
You can easily keep your opponents away from farming creeps by using tumble when he/she tries to farm (just tumble-hit then back... if u do that a couple of times enemy player will start to play passive or die when trying to kill you :P).
Your first item after boots should be Sheen because it works like a charm with tumble. Then you gonna need some life steal so you should get vampiric scepter.
Once you have Trinity Force enemy team better watch their back as you have really good damage for your level.
Sword of Divine is one of the best items for Vayne as it gives you attack speed and when you activate enemy cant dodge your attacks (come here Jax i will own ya!! :p)
When you have Bloodthirster you are a beast now. It's time to have more survivability. It depends on enemy team now. If their AP champs doing well first get Banshee's Veil then Frozen Mallet, if their AD champs doing well get Frozen Mallet first.
And I wanna add that i see people getting Madred's Bloodrazor for her. Its just doesnt worth that gold as you already have Silver Bullets (they should kill warwick with only 1 hit but nvm :p if they did, people woulda start to whine about Vayne is OP!! :p)
One of the games, enemy banned Vayne so i played Twisted Fate(He was my main AD ranged before Vayne came out) ^^
Meeh I've lost one but who doesnt?? =)