Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
This is my Vlad AP Nuke build. It works best if you go mid but can work if you go solo too.
Vlad works best as utility since his ult plus ignite is uber, and so is ghost then his pool. Plus defense has nuthing for him and offense is too melee based.
Pretty solid. Just grab a butt load of AP and MPen. If you are pwning da noobs switch out morellos/ancients for a mejais.
Grab transfusion then pool then your E. After words work to max pool then transfusion and your E is the last to be maxed out.