Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
This build is based on running in with massive amounts of HP and AP. This build has worked several times about 99% of the time with good results. The item build shows the order I personally get my items in but not the order you need to follow. IMO stacking hp on vlad is extremely good. Vlad's passive converts bonus HP into AP and bonus AP into HP. Having a high HP will allow more damage output and keep you alive longer so I say stack that up early!!!! Comments are appreciated good or bad. This is my first build so don't be TOO harsh :]
Start the game in mid and stay behind your minions. Harass people with transfusion while farming the minion kills as they run. About level 5 or 6 you should be getting your first kill, and around 7 it is safe to turret dive as long as sanguine pool isn't on cd. Keep an eye on both top and bottom lanes and after killing the champion in middle go to either lane and help gank. This build is basically done here at level 12, only thing left is to buy items and farm kills to make yourself deadlier. Pretty much rinse and repeat for the full game building up items as needed.
If Stacking HP correctly you should be sitting around 5k HP and 500 AP around the end game (assuming it lasted that long)