Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
5's HP/AP build. This is the build I found best for me after about 15 games playing Vlad.
Start - Build works if u play mid or lane with a buddy but better mid. Start is easy spam Q for last hits on mobs and on your enemy when u can to keep them back. Use the pot or heal if u get low. I like to use the pot first so I can save heal for when going for a gank. You should be able to hold your lane np until you get 2k gold and go back to buy.
Mid - By now your Q is maxed and you have Rylai's Crystal Scepter. At this time you can start running ganks top or bot till the towers are down.
Late - You end up with around 3400 HP keeping you in the fight end game. Start fights with your Ult then E followed by W so you can't be made first target. When you come up spam Q till your foes are dead. If you need to run and W isn't up use ghost.