Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
This is my vladimir nuke build.
Runes: For runes i choose the ap runes, health, magic penetration.
-Ghost= best for running away from nukes. Activate ghost+sanguine poll= no way of cathing you.
-Ignite= In combination with Hemoplague its the best for ending enemies.
Items: I ussualy dont play on Zhonyas Hourglass since they dont nuke me so fast. I just make 2 Rabadons Deathcaps... But it really depends on the game. Its the same thing with Void staff, if you see your enemies building up magic ressist then you should buy Void staff, if not just buy Rabadons Deathcap.
Thats as simple as it gets. Hope you nuke your enemies as much as i do. I ussualy get scores of 27-2 15-0 11-0 and stuff like that.
Have a good day IRONHELL