Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
At level 18 with max stacks Vladimir will have 5000+ HP and about 500 AP. Unfortunately he doesnt have much armor and magic resist. Your main spell is Transfusion which does like 500 dmg late game and its cooldown is unbelievably fast so you can just keep spamming it and watch your enemies life drop while they say wtf is that? Plus its great for last hitting minions during the entire game and great for harassing, hey it has no cost so why not just keep using it? Sanguine pool is an awesome skill. It lets you initiate and escape easily, plus it slows and does a great amount of damage too. In my opinion Tides of Blood is pretty weak. 300 some damage late game and it hits anyone close to you. I thought it use to heal nearby allies buy i guess they changed that. I guess if you use it constantly and get the buff up it would do pretty good damage but the cost gets higher depending on the buff. I usually use Hemoplague somewhat early in team fights because of it increases damage taken, then after 5 seconds it does like what 700 to who ever is infected which hopefully will land you couple kills. Overall I think Vlad is a great champ. He needs some tweaks in my opinion because he seams really weak, but if you play him right Vlad is an insane killer. Try this build out and I promise you that you will dominate the other team, but remember it's mostly the players skill that counts.