Hi ,it's me again.If u Like this build u might check my other ones:
Katarina ,Hybrid is All i Need
Not Mine,but still good Lux build.Maybe his english is not perfect,but still tips and item build rocks
Lux Demacia ap nuke build

Introduction

Hey.This is my Vladimir AP/Tank Nuke build.Its my favourite and honestly ,best vladimir build. You can deal insane dmg(900+ with transfusion) while having huge amount of hp (my personal best 5400 at lvl 18).It's my first build ,so feel free to comment.If u want to -1 it ,please leave a comment with criticism.

@EDIT 03.12.2010
Due to suggestions ,i changed item build a little bit ,and reworked skill order.
@EDIT 22.22.2011
Woah it's been a long time.Changed zhonya for Deathcap ,and Will of the ancients for 2nd rylai's(old build ,it seems to be better one)

Skills

Crimson Pact

Every 25 points of bonus health gives Vladimir 1 ability power and every 1 point of ability power gives Vladimir 2 bonus health (does not stack with itself).

It might be the best passive ingame.Just Stack Ap ,or health and you still are Tanker/Nuker.Just love this one.

Transfusion

Vladimir drains the lifeforce of his target, dealing 70 / 115 / 160 / 205 / 250 (+60% of ability power) magic damage and healing himself for 25% (+100% of ability power) of that amount.

Main Vlad skill.Damage output and low cooldown makes it one of the best harass and nuke spells ingame.

Sanguine Pool

Vladimir sinks into a pool of blood for 2.5 seconds, becoming untargetable and slowing enemies above him by 50%.

Vladmir deals 15% of his bonus Health in magic damage over the duration and heals himself for 12.5% of that amount.

One of the most annoying spells ingame.While u are in pool ,no1 can damage you ,even karthus or nunu's ultimate.It's good chase and run spell but be carefull while using it ,it cant kill you ,but you loose 20% of your actual health ,so use it wisely

Tides of Blood

Vladimir unleashes a torrent of blood dealing 60 / 90 / 120 / 150 / 180 (+45% of ability power) magic damage to nearby enemies.

Each cast gives him an Empowered stack (max 4), increasing his healing and regeneration by 8% each. Additionally, his next Tides of Blood deals 25% more damage and costs 50% more Health per stack.

I cant say many things about it.While stacked to 4 stacks it deals HUGE AoE damage to all units surrounding you.Use it for harrassing too ,and dont forgt to spam it in teamfights.

Hemoplague

Vladimir infects the target area with a virulent plague. Affected enemies take 10 / 14 / 18% increased damage for 5 seconds.

Good ,but not best ultimate.Cast it while starting a fight ,it increase damage u deal to the target.Combo looks like Hemoplague->Transfusion/Tides of blood.Easy ,isnt it?But believe me ,it's pretty deadly :)

Runes

Magic Penetration Marks for early game dmg raise

Ap per lvl glyphs for ap boost .They can be replaced with cooldown reduction one ,it's ur choice

HP per lvl seals.They grant more life than flat hp seals.For quints ,go flat hp.

Masteries

For Masteries i go 9/0/21 ,9 in Offense for 15% Magic Penetartion ,and 21 in Utility for cooldowm reduction ,movement speed etc.You might consider going 9/21/0 ,it's viable for vlad too i think

Summoner Spells

Ignite:

For me,Best possible summoner's skill.It's must-have for Vlad.Healing decrease is sweet and it stacks perfectly with hemoplague.

Ghost:

With Sanguine Pool u escape every gank ,and u gank everyone.Needless to say ,2nd must-have for vlad.

Items

Ruby Crystal:With your runes ,it provides you 777(:D)hp at lvl 1.It gives you huge advantage against teemo or other squishy chars.With your hp per lvl runes ,at lvl 3 u should get ~1000 hp . Huge ,isnt it?

Haunting Guise:AP,HP and magic penetration.With marks ,mastery and this passive ,u penetrate every magic resistance ,so you deal full dmg to enemy.Also ,it costs ~1500 only.Best choice for early game.

Sorcerer Boots:Another Magic Penetration ,usefull when enemy is stacking magic resistance . Dont forget that penetrating enemy's whole magic resistant make's your attacks deal more dmg thatn usually.

[color=red[Mejais Soulstealer[/color]/Rylai Crystal Scepter:Depending if you are killing or not.If you are ,grab Mejai ,and start collecting your stacks.If not ,grab Rylai before Mejai.Why?Because it applies slow on enemies and gives you AP and HP.WIth your passive ,its 100 ap and 660 hp.

Zhonyas Ring:120 Ap+passive+active.It's a must when u play any nuke. It also gives u 240+hp.

Items you might Consider

Will Of The Ancients"Many people commented that they would have changed third rylai for Will of The Ancients.And ,after few test ,i find it working brilliant.Ap Aura ,which is very helpfull for your casters plus 20% spellvamp.That 20% gives u the edge between kill or death sometimes.Im Still testing that item ,because it might be more usefull than haunting guise early game ,due to that spell vamp.Still in test ,i will let u know what i think about it.
Edit@
I think that it depends on your playstyle.I usually grab ruby crystal 1st ,but grabbing tome is also good.If u go for Tome ,i suggest to change 1st item (Haunting Guise) for Hextech Revolver.It gives you enough heal potential to stay on lane as long as you want.

Void Staff:40% Magic Penetration?lets calculate:40% from that item +15% from Masteries=65% Penetration.Add 9 from runes ,and about 40 from boots and guise ,and what do you get?Those tanks are no matter for you ,doesnt matter how many hp they have ,they become as squishy as his carries.I will let you know what do i think about this item later ,after few tests.


At last ,i want to apologize for my english.Yea i know it sucks ,but i was trying to do my best :).Feel free to rate and comment.

Here's example