Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
I like to play Vladimir. Then i play vladimir i wanna to have much more ap i can have, BUT dont forget about survivality.
I think in league of legends runes help peoples in early game. that why Hp Quints, Ap glyphs and seals, and magic penetration marks.
Of course Transfusion is first skil we need to learn. After lvl 9 we have 3 secondes cd on it and have pretty much damage. I wish to learn Tides of Blood second beacose with Will of Ancients we have good heal in team fight and good damage. We need pool only on lvl 1. i dont see any sence to lvl up it earlyes than tides of blood.
This item build have ap, spellvamp and hp. in late game we have a enought hp to dont die in team fights have good spell vamp buff for team and many of slows. i think on vladimir this build looks perfectly.
Ghost\Ignite best spels for vladimir. With Ghost we can run away if we need and get a running away kill. ignite have more dps and with masteries on ignit more ap. More ap=More dps= Profit.