I changed a few things and i see what you are saying but you really dont need much health regen with your E and that's why i didn't get that.

you need a point in:

-ARCHAIC KNOWLEDGE (this helps your ghouls dmg alot).

I noticed in my match history that ~ 35% of my dmg output was MAGIC DMG!! So instead of getting +1% attack speed, get +15% magic penetration.

Also, since your building manamune... u should play 21/9/0 with 3 defensive points in:

-'Strength of spirit'

Health regen
1% of 500 mana = 5.2 hp per 5
1% of 1.3k mana = +13 hp per 5 (i dont know about u, but i usually complet my manamune at around 1.3k mana, to make it worht while :P)
1% of 2k mana = +20 hp per 5

much better then 2% of your base hp regen -.- and you dont need mana regen when you have tear and the occasional blue buff

I would not use hp glyphs, ever. Maybe hp seal and mana regen glyphs...

So i cant vote as in...
-5L1V3R

this is like my toliet, very clean and sleak. i hope to fish oneday as much as i can

I found this guide to be quite helpful! First game I went 0-8-7 liek a fish! Very pleased!