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wins lane vs you and duels you pretty easily but you outscale her so hard that you actively have to be loosing hard to be less useful than her in the game.
Akali
A skilled akali will zone you from wave and you will have to play the lane very patiently and drop a few cs but you outscale her and ur E triggers "shimmering" in her shroud later on making her very weak vs karthus in teamfights unless very fed. play safe and u outscale.
Annie
free lane usually if u use w properly she cant find good engages on u in lane
Cassiopeia
You win if you dodge her ult really hard so just play around doding it in duels in lane. as for scaling she tends to scale a tiny bit better but karthus is way easier to play in late so if she isnt very good you will have the edge.
Corki
free lane just track his roaming when u hear package sound and ping ur teammates.
Ekko
can easily setup dives for his junglers by shoving with q and using w under ur tower u need to respect his kill pressure aswell at all times but since ur range u can abuse range difference and farm safe in lane its okay to drop cs since if he does not get a major lead you should be more useful.
Diana
good dianas will abuse u with q poke since they know they have way more kill pressure than you but as most assassin matchups u can drop a few cs and just make her not get a lead to outscale
Fizz
very hard matchup you need to always respect his all in and be ready to dodge or flash his ult when its up, you outscale really hard if he does not get a lead.
Galio
free lane and u outscale him really hard
Aatrox
play around range advantage
Irelia
easier than most melees because she needs to go in super hard, just dont get too behind before u have 2 items and she cant play anymore zhonya demonic are too powerful vs her
Karma
free
Kassadin
really hard matchup as he can just safe and outscale u and he starts beating you very early on (lv6+ mark alrdy hard) just ban kassadin u need a lead and good team around to win
Katarina
dodge her daggers and just play for 2nd item demonic spike with an oblivion orb and she has a very hard time. She needs her jungler to get a lead if you play waves properly.
LeBlanc
hardest matchup in the game for karthus, you have two options play normal rune page and build and hope she is bad and her jungler doesnt gank you or play aery insp cookie corruption potion and play to go even in trades and cut ur scaling. dodge in champ select for best results.
Lissandra
free just hit ur wall and she cant do anything vs ur e dmg and q cuz of her short range
Lucian
play very safe a good lucian will bully you alot u will have to give up cs, if he doesnt get a major lead u outscale.
Lux
just play around her q and u win and outsustain her
Malzahar
free just respect when he walks up in case his jungler is there for his ult followup but alone he cannot deal with u and u even outscale him he has few options but jungle help
Neeko
her root is very dangerous she has good jungle setup but if she doesnt get a lead u outscale
Orianna
just safe farm lane u only die if u disrespect her or her jungler, scaling is pretty even but ur champ is easier to play so u have the edge
Pantheon
buy armguard and farm safe if he does not get a lead u outscale
Qiyana
very scary lane you have to respect her alot but at 2 items u outscale so just drop a few cs and make it to midgame
Ryze
he just beats you in every trade and in scaling very hard matchup u have to rely on playing for jungler and bot
Seraphine
get oblivion orb after mythic and you will be more relevant than her in 5v5
Azir
free lane u outscale and outrange just be wary of his all in with ult around his jungler
Sylas
just dodge his 2nd e and he cant play and he loses relevancy the longer the game goes
Syndra
free lane just respect her all ins with junglers around, if she doesnt get a major lead she is fucked.
Talon
very tough for your jungler try to calm him down in chat. u outscale him if he isnt ahead at 2 items
Tristana
very hard just try and play for your junglers leads more than ur lane
Viego
easy in lane but out of lane he just outscales u and 1v9s get antiheal and hope ur team can shut him down in 5v5 cuz u cant
Veigar
very even matchup very team dependant u dont really kill him in lane but he cannot kill u unless u troll or jungler interviens
Vel'Koz
respect his range advantge, u are alot better in 5v5 so play for jungler and team
Viktor
he wins lane but u are better in 5v5 he will harass alot so its fine to drop a few cs instead of dying
Vladimir
very hard if vlad gets a lead, he outscales u aswell so pray ur team can shut him down cuz u cant
Xerath
he wins lane but ur wall is really good for jungle setup and u outscale him
Yasuo
easy matchup at 2nd item u win really hard just dont give in to his aggression as he wins early abuse range and sustain mana in lane for free
Yone
hope to god he does not get a lead before u have completed zhonya u can even rush it just to prevent his dives at 3 items u are even in impact but a very good ban
Zed
get zhonya 2nd and he cant play before that just respect his all ins and play for lane sustain and not trades or all ins, u can bully him before 6 aswell.
Fiora
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Camille
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Irelia
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Riven
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Renekton
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Darius
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Tryndamere
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Olaf
bruiser ad junglers are really good pairing with karthus in 2v2 river and for teamcomp.
Kayn
bruiser ad junglers are really good pairing with karthus in 2v2 river and for teamcomp.
Rengar
very good with karthus ult
Nocturne
his ult with ur ult is exteremly obnoxious to play vs
Synergies
IdealStrongOkLowNone
Fiora
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Camille
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Irelia
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Riven
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Renekton
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Darius
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Tryndamere
u want strong ad top cuz they get alot from having karthus ult throughout the whole game.
Olaf
bruiser ad junglers are really good pairing with karthus in 2v2 river and for teamcomp.
Kayn
bruiser ad junglers are really good pairing with karthus in 2v2 river and for teamcomp.
Rengar
very good with karthus ult
Nocturne
his ult with ur ult is exteremly obnoxious to play vs
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