This build is mainly for if you are going to be fighting a real tanky team or if you are going to need to really help out in team fights to eat away at the enemy's armour.

Runes are more of your choice, but I just tried to put in a half and half of AD and AP. If you want to edit the runes, go right ahead. I stress that you really need the quintessence that gives you the energy though.

Overall in masteries you need to build all of the AP slots that they give you and fill in all of the AD slots along the way. I do recommend putting a couple of points into defense because Akaki is super squishy early game.

The main goal of the skill sequence is to max your Q, then E, then W. Until around level 16, the only time you should get your W is at level 2. The reason for this is that you need to pack extra damage with your Q and E and the only time you will need your W is in a chase or gank, so the unupgraded W will make due until you max out your Q and E.

Spells aren't a huge part of Akali, but they do help. I choose heal because Akali is so squishy, mainly early game. The flash is overall for basic use, I like it for when I turret dive. The reason I didn't use ignite is because late game Akali really just doesn't need it and you start wishing you hadn't used it. If you want to use it though feel free to.

The three health pots you get first with the boots will help you lane longer so that you don't have to recall so often early game. I chose boots of swiftness because it complements Akali's crazy chasing skills. Next is Malady which gives you some attack speed and some AP. Later on if you feel you are dieing a lot, you can sell that and build Warmog's Armour. Next is your Rageblade and Gunblade. These both give you AP and AD with nice passives. And finally you want to build a Rabadon's Deathcap to get you're extra AP and a Black Cleaver to get your extra AD. If you really want to you could always get a Trinity Force mainly for its passive.

Akali is very deadly with AP (which I will make a build for later) but not very affective when an enemy builds mage resist. That's why a hybrid build is important for her. You can eat away at their armour both ways. This makes it easier for your teammates to deal extra damage to them as well.

The worst thing you can do with Akali is run into a 1v2. Even late game you won't have too good of odds. The only time a recommend this is when you sneak up behind them when they have low hp.
If you see a weaker enemy champion entering the woods, cut them off and wait in a bush for them. In a get away always use you W to make and escape. You're W can also be usefull if a teammate is getting chased, or in a teamfight. The best way to use Akali's bursting damage is to just go for champs with about half hp and wreck them.

Pros: You will be able to deal both AD and AP damage. This makes it so that it is hard to build against you.
Cons: You won't really be able to deal a large amount of AP or AD like you would if you build only AD or AP.

Jungling is not something you should ever do because Akail is so squishy. Creeping however is a good idea if theay don't have a large tank on their team ex: Mundo, Sion, Nautilus, ect. Going into the jungle and waiting in a bush can be a good idea if you have been fed.