**Teemo Optimal Build and Rune Setup:**

**Runes:**
- **Primary (Domination):** Dark Harvest, Taste of Blood, Ultimate Hunter, Grizzly Mementos
- **Secondary (Precision):** Legend: Alacrity, Cut Down

**Core Items:**
1. **Liandry’s Anguish**
2. **Bloodletter’s Curse**
3. **Shadowflame**

**Boots:** Flexible (Sorcerer’s Shoes for damage, Plated Steelcaps for defense)

**Build Strategy Explained:**
This Teemo build elegantly maximizes damage output across the entire health spectrum:

Start with **Liandry’s Anguish**, leveraging its burn effect for continuous damage amplification from your shrooms (Noxious Trap). Pair this with **Cutdown** from your runes, which adds up to an 8% damage boost against high-health targets, effectively amplifying your top-end damage potential. Next, **Bloodletter’s Curse** complements this setup by shredding enemy magic resist (MR), increasing shroom effectiveness while adding defensive durability to sustain longer fights.

Finally, **Shadowflame** perfectly rounds out your strategy, granting up to 20 magic penetration and offering up to 20% increased damage against lower-health enemies—covering the bottom-end of your damage curve by delivering reliable burst against squishy opponents. Additionally, runes like **Cutdown** combined with Shadowflame create a seamless damage profile: you're maximized against both full-health and low-health targets.

Boot choice remains flexible, depending on matchup pressure—**Sorcerer’s Shoes** for aggression and amplified burst, or defensive options like **Plated Steelcaps** for survivability.

This setup leverages intelligent rune-item synergy (e.g., **Cutdown** with **Shadowflame**) to elegantly balance damage extremes, creating consistent threat throughout the game and ensuring optimal scaling from early lane pressure to late-game dominance.