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Well, I used to mostly play Veigar or Yi and be pretty sucessful so I decided to try pantheon because most I see are pretty terrible with the ult and wanted to see how I would do.
First with the runes:
Red: Armor pen, works with his spear, heartseeker and his melee attacks
Yellow: Health, to be able to be a bit more aggresive early
Blue: Mp5 to spam the spear
The main idea for early game 1-6 is to harass with spear enough to get them to around 50-60% by the time you get to level 3 so you have to be very aggresive with the spear
Once you're lvl6, and yyou're playing someone with a lack of hp and you have them at 50% it's a kill everytime, you run in like you're just spearing, you spear, jump, heartseeker, ignite, and spear and there's NO WAY they'll live, just watch to see if they have heal
Then, as soon as you're 6, you jump on a lane with low hp, dont even hesitate, just ping and go, and you dont jump on them, you jump behind them, then you teemates go after them, 90% of the time they run back into it and get destroyed
Late game same thing, push lanes, keep an eye on your map and try to jump into team fights, the best way to do it late game is jump in the middle because they'll split up and should be an easy kill or two for your team, your team just needs to know it's going to happen