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Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
This is support build example for Karma.
Heavenly Wave: Karma sends forth a wave of hidden blades from her fans, dealing magic damage to units in a cone in front of her.
Mantra Bonus: In addition to dealing damage to enemies, Heavenly Wave will also heal allies in the cone. The amount healed is amplified depending upon the amount of life Karma, or her allies are missing
Spirit Bond: Karma bonds an ally or enemy creating a beam between them. Bonded allies have increased movement speed and bonded enemies have reduced movement speed. Enemy units that come in contact with the beam take magic damage, and champions who pass through the beam receive the same movement speed modifier as bonded champions.
Mantra Bonus: Karma imbues the beam to grant bonus movement speed to any ally that passes through the beam. Any enemy that passes through the beam suffers reduced movement speed. Karma strengthens the bond to double the effect of the movement speed modifier.
Soul Shield: Karma summons a protective shield that absorbs incoming damage.
Mantra Bonus: In addition to the shield, energy radiates out from the shield, dealing damage to enemy units around the recipient.
Mantra (Ultimate): Karma empowers her next ability to do an additional effect. Mantra is available at level 1 and does not require a skill point.
Inner Flame (Passive): Karma gains increased Ability Power corresponding to her missing Health.
You can make Shurleya's Reviveafter boots instead of Will of the Ancientswhich is making in late game.
Doran's ring: improves your mana regen, harrasment and survi in early game.
Mercury's boots: Magic resist is important for support, because most AP champs are ranged. Karma's beam ability let run away easly from melee champ. Support cant be stopped by stun for long time so 35% less CC's duriation from this boots is for you.
Spirit visage: Improves your survi(HP nad Magic resist), healing on yourself from Q ability and your cooldowns reduction for using your abilities more often to help your teammates
Soul shroud: Aura support(mana regen and CRD) and survi(HP) like above - that are the most important stats for support.
Rylai's Crystal scepter: AP for better heal and harras, improves your slowing ability, and survi (HP)
Will of the Ancients:AP for better heal and harras, but this time for your team too by AURA effect :). Now u can heal yourself bu using Q spell or E spell with your mantra (spell vamp). Your team will enjoy it with big smile on their faces like Ryze which after one combo will be healed from half of HP to full :D
I cant write nothing more because I didn't practice her in game(patch is in progress at the moment^^). That are my SUGESTIONS ONLY. Sorry for my english ;).