Vayne is a hypercarry champion in League of Legends, and she's particularly strong against tanks due to her W - Silver Bolts ability, which deals true damage based on a percentage of the enemy’s maximum health after every third attack. This makes her highly effective against tanky champions who build a lot of health and resistances, as her true damage bypasses armor and magic resist entirely.

When paired with the Hail of Blades rune, Vayne can get her three-hit passive off much faster, allowing her to burst down opponents quicker. The extra attack speed from the rune synergizes well with her kit, especially in the early game, letting her rapidly proc Silver Bolts. This combination makes Vayne even more lethal against squishies and tanks alike, as she can shred through their health bar with ease.

Overall, Hail of Blades amplifies her dueling potential, making it easier for her to kite and kill opponents quickly, especially tanks who rely on their health to survive. This makes her a formidable champion in both 1v1 situations and teamfights.