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Not Updated For Current Season
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This build will allow you to successfully kill all champions without dying.
He's a easy champion to master as long as you don't get greedy and chase.
The AP will make your spells really powerful compared with the majority of the other casters and the magic penetration will make them sting as hell !!!
If you go with top or bottom lane try to hide in grass as fast as you can and as soon as the first enemy comes close to the grass use spell flux (it will bounce on you) and will take half HP of any champ almost every time.
Just a little something before i get into the game play.
My skill build can be adjusted to better suite the champs you are facing on the lane but 80% of the times i feel this build is the most efficient.
You'll start with the best harassment spell and also one of the most powerful spells from ryze (spell flux) so you can keep them in check wile getting minions to lvl a bit.
The rune prison to make them stay to take more damage from spell flux.
For me learning just a lvl of overload is enough for early game as the other spell are way more efficient to gank/kill other champs (spell flux) and to keep you safe (rune prison).
But this is just my point of view and the following description is a sketch of the majority of my games (it's not 100% what will happen but you want it to be close to successfully use this build)
Start with buying Dorans Ring with an Health Potion and you'll be fine till lvl 5/6, time when you'll have just enough for 2 things.
Try to gank as much as you can remembering the one rule wile playing with ryze.
You are squishy and other champs know that ... so you'll be the first target almost 80/90% of the times during a game wile in a group run.
If you run alone you get killed easily or if you get too greedy and run after a low hp champ alone you will probably have the same fate (as you most likely will be ganked by they're team mates quick !!!)
Learn your place, be patient and look for good opportunities to kill.
Once you have all items, you will mostly be unstoppable, just watch out for the gank. Your spells will kill most heros that do not have tank health such as Master Yi and Tristana.
The summoner spells may vary with your preferences or game style ... clarity is a must for early mana boost and better ganking/harassment, as for the heal well, as you know your life is not that good and in a tight situation it can make the difference between getting to the tower and teleport back to heal or dieing :S Although it's a bit bad late game (i admit that) can easily be changed to teleport or (peoples most picked option) flash. Either way good options !!!
Thanks for reading this big wall of text *sigh* and hope you like this little "guide" !!!