Twitch is a very good assassin. Map does not represent any danger for him. To see wards opponents if necessary you can use to start an oracle. The strongest and most useful skill in 1 vs 1's is (e) => Expunge. It's fun to play with it but also very dangerous, if you're new to the vegetables of Legends I would advise you not to play with him first. For afansati but work otherwise. Remember Twitch is based on the team, he attacked the shade or go back in the last teamfight last. GL & HF

You might wonder why I chose these runes? I'll explain, because tiwtch has the lowest life game, why runes are perfect to enhance his strength but also a better start. Now it's up to you, but for this build are the best runes. Once you complete the 1vs1 build you should have no problem.