This is the ultimate guide to Vayne (the evil thing denier). Vayne is really squishy at the start of the game, so always get a dorans blade as a starting item. If your support does not have sustain like sona or soraka, you should get boots and pots to keep your vayne (tank destroyer)in lane to farm for more gold and xp! With masteries and runes, go with crit strike, armor penetration, and bonus damage. That selection is so you can trade damage with your enemies better. ALWAYS MAKE YOU SUPPORT WARD THE RIVER AND BUSHES TO PREVENT GANKS. A low hp vayne is a one-hit KO. Always farm, condemn and tumble to escape or to attack, and play smart. Vayne has many qualities but it is hard to master. Have fun destroying opponents.