Ye, look right, my pure nuke Vlad is there, #3 if I'm right.
Nevermind thou, Vladimir got that red pinging thing above his ******** head and was attacked with BAN HAMMER. It wasn't super effective, yet it dealt critical damage and he can't be build without Ionian Boots of Lucidity. Back when I wasn't a real fan of these, now I find them just hilarious, too OP on Vlad/Kata.

So, stay for a while, get something to eat, you can take this cool beer from the fridge and enjoy the shiz I made.

What we do like and what we don't about that blood sucking half-teen, half-old-geezer guy.

Pros:

High Sustainability
All 'round useful skills
High HP and AP
Game Changing
Impossible to kill, if farmed/fed (learn how to last hit *****es and own)
Variety of 1-Target Nuke and AoE abilities makes him a great fighter overall
Easy to play, **********a hard to master (ye, haters, ye)

Cons:

Low CC, only a mere slow, can be used to save allies (ye, it can)
CC -> you're dead in theory, you hate this word, it's your forbidden phrase
Vlad with no farm is a weak Vlad, keep that in mind
Must...learn...how...to...last....hit (ye, if you can't don't use him)
Defense -> Offense -> Pwnese (e.g Early-Mid-Late)
Targeted first (noobs, who don't focus Vlad down fast, are Noobs, ahue)

Ye. Farm. This is where Vladimir outshines almost all characters. He can clear a 5x minion wave in 4 seconds, how?! Because he is Vlad. The ones able to match/overtake him there are Miss Fortune, Tryndamere, Tristana, Malzahar and Corki. He is tottally in the Top 5 Farmers in the game.

Since I see *****es failing with his last hits, let's make it clear:

Caster Minions:
The strategy is very easy. The thing is, Vlad has about 0,1 reaction time before he attacks (his hand is moving back), try waiting until the CASTER minion is a bit low and hit.
About Turrets - if CASTER wave is near your turret, block them and hit each 1 time with auto attack then let them get to turret and hit immediately after the turret hits them. Profit.
PRO TIP:Until you buy any items you can use Tides of Blood to do this and save some time on those first attacks.

Melee Minions:
Ye, you need good timing here. Once you hit level 7 you can spam your Transfusion to finish them as well (profit garen-teed), but once you learn how to last hit them it's cool. Keep in mind that they have some armor, not much, but that can screw your last hit.
PRO TIP:Wait until they are tottaly low or just give them few auto attacks before so you know how much you do them (works good for last-hit beginners).

Tank Minions:
Wait with Transfusion. Ye, just like this, you need their profit to be garen-teed.

1. You are looking at the build ****.
2. You think it's cool.
3. You see second Hextech.
4. You downvote ASAP.
5. STOP!

Why Double Hextech, Hell my friend. You see...
It's fun. Get that Will of the Ancients and Hextech Revolver, Troll with 40% Spell Vamp.
Profit - 300%, owning faces with it, son. Abuse it.

Ye, I'm dead serious, guys. This option is just OP.