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Karthus Build Guides, Runes and Items

Karthus The Deathsinger

Find the best Karthus build guides for League of Legends S13 Patch 13.6. The MOBAFire community works hard to keep their LoL builds and guides updated, and will help you craft the best Karthus build for the S13 meta. Learn more about Karthus' abilities, skins, or even ask your own questions to the community!

Karthus Build & Runes

If you're looking for the best rune build for Karthus we've got you covered. Below you can find the best items and runes to build for Karthus, as determined by calculations of thousands of Plat+ League of Legends games. If you are already familiar with how to play Karthus this is a great resource to quickly get a good rune selection for Patch 13.6. However, if you are a new Karthus player we highly recommend reading through some of the guides above to learn why this build is strong on Karthus!

Patch 13.6: 691458 matches scanned * Each section of the build is rated independently of the others

Karthus's Runes

Karthus's Best Runes 49%

Win Rate 11954 Games

  • 1
  • 2
  • 3
Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Treasure Hunter
Treasure Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Coup de Grace
Coup de Grace

Second Best

Karthus's 2nd Best Runes 49%

Win Rate 3345 Games

Inspiration
LoL Path: Inspiration
LoL Rune: First Strike
First Strike
LoL Rune: Magical Footwear
Magical Footwear
LoL Rune: Future's Market
Future's Market
LoL Rune: Cosmic Insight
Cosmic Insight

Domination
LoL Path: Domination
LoL Rune: Ultimate Hunter
Ultimate Hunter
LoL Rune: Eyeball Collection
Eyeball Collection

Third Best

Karthus's 3rd Best Runes 56%

Win Rate 2140 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Treasure Hunter
Treasure Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Karthus's Summoner Spells

Karthus's Best Summoner Spells 51%

Win Rate 18144 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Summoner Spells 48%

Win Rate 12583 Games

Flash Smite

Third Best

Karthus's 3rd Best Summoner Spells 43%

Win Rate 166 Games

Smite Ignite

Karthus's Starters

Karthus's Best Starter Items 51%

Win Rate 10332 Games

  • 1
  • 2
  • 3

Trinket

Karthus's Best Trinket 50%

Win Rate 23916 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Trinket 90%

Win Rate 259 Games

Eye of the Herald

Third Best

Karthus's 3rd Best Trinket 44%

Win Rate 4759 Games

Stealth Ward
Don’t forget
to Buy Wards

Karthus's Ability Order

Karthus's Best Ability Order 65%

Win Rate 12997 Games

  • 1
  • 2
  • 3
Patch 13.6: 691491 matches scanned * Each section of the build is rated independently of the others

Karthus's Runes

Karthus's Best Runes 56%

Win Rate 2772 Games

  • 1
  • 2
  • 3
Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Taste of Blood
Taste of Blood
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Second Best

Karthus's 2nd Best Runes 57%

Win Rate 1240 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Third Best

Karthus's 3rd Best Runes 62%

Win Rate 105 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Treasure Hunter
Treasure Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Karthus's Summoner Spells

Karthus's Best Summoner Spells 55%

Win Rate 6172 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Summoner Spells 59%

Win Rate 83 Games

Exhaust Teleport

Third Best

Karthus's 3rd Best Summoner Spells 53%

Win Rate 430 Games

Flash Teleport

Karthus's Starters

Karthus's Best Starter Items 54%

Win Rate 11546 Games

Trinket

Karthus's Best Trinket 58%

Win Rate 4059 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Trinket 50%

Win Rate 2706 Games

Stealth Ward

Third Best

Karthus's 3rd Best Trinket 55%

Win Rate 325 Games

Oracle Lens
Don’t forget
to Buy Wards

Karthus's Ability Order

Karthus's Best Ability Order 66%

Win Rate 907 Games

  • 1
  • 2
  • 3
Patch 13.6: 691478 matches scanned * Each section of the build is rated independently of the others

Karthus's Runes

Karthus's Best Runes 62%

Win Rate 108 Games

  • 1
  • 2
  • 3
Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Second Best

Karthus's 2nd Best Runes 58%

Win Rate 93 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Coup de Grace
Coup de Grace

Third Best

Karthus's 3rd Best Runes 55%

Win Rate 183 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Taste of Blood
Taste of Blood
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Karthus's Summoner Spells

Karthus's Best Summoner Spells 51%

Win Rate 1756 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Summoner Spells 49%

Win Rate 1777 Games

Flash Teleport

Third Best

Karthus's 3rd Best Summoner Spells 53%

Win Rate 103 Games

Flash Barrier

Karthus's Starters

Karthus's Best Starter Items 51%

Win Rate 6974 Games

  • 1
  • 2

Trinket

Karthus's Best Trinket 53%

Win Rate 1789 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Trinket 47%

Win Rate 1966 Games

Stealth Ward

Third Best

Karthus's 3rd Best Trinket 52%

Win Rate 390 Games

Oracle Lens
Don’t forget
to Buy Wards

Karthus's Ability Order

Karthus's Best Ability Order 61%

Win Rate 1097 Games

  • 1
  • 2
  • 3

Karthus Counters

Learn Karthus' counters and discover matchups where they have an advantage! When you're starting a game of League of Legends you should always keep in mind if you'll be at an advantage or disadvantage against your opponent, so you can know whether to bully them or play safe. You can find detailed breakdowns of each matchup on CounterStats, and you can also check out some Karthus guides to see how to build and play against other champions you may find yourself up against!


This counter data is for Karthus Jungle in Plat+ games. The percent shown is the enemy champion's counter rating against Karthus. Counter rating is our own statistic that factors in counter kills, overall kills, early lead ratio, comeback ratio, and win percent to give the whole picture of that champion's effectiveness as a counter pick.

Karthus Skins

Karthus' Abilities

Questions About Karthus

League of Legends Champions:

Teamfight Tactics Guide