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One of Cassiopeia's easiest matchups. You outharass and out DPS him ten times over. Make his laning phase a living hell because he scales in a fashion very similar to you. Harass him whenever possible, and don't be afraid to trade with him, as you should win all 1v1 trades. Consider buying a zhonya's mid game to counter his ultimate.
Ryze
Ryze is probably Cassiopeia's easiest matchup. All of your skills outrange him, and he has to face you in order to use his combos. When he goes to combo you post-6, just ult him in the face. During the laning phase, harass him to hell, and outscale him into the late game. Due watch out for his burst early though, if the ryze is good he can do some damage.
Twisted Fate
Twisted Fate is super easy to deal with. You outrange, outharass, and outscale him into the late game. Early on, make sure you are harassing him to hell, do not let him farm. Twisted Fate has an awful early game and laning phase, take advantage of that. Once he hits level 6, make sure you keep him pushed to his tower so that he can't roam. If he ults another lane, punish him by taking his tower.
Annie
Annie is easily manageable. You outrange her in practically every way. However, if she ever makes an aggressive move towards you, be prepared to flash out of her flash + tibbers combo. If she gets ahead in lane, buy an early negatron cloak and rush Rylai's Crystal Scepter or Abyssal Scepter if there are multiple APs on the enemy team. Otherwise, RoA into Rylai's should make you plenty tanky to survive her burst.
Kassadin
Kassadin gets destroyed in lane by Cassiopeia because she can utterly deny him any farm with her harass and zoning potential. Be incredibly aggressive, don't let him cs unpunished. Post 6, push his lane to his tower and roam. If he follows you should be able to kill him because you should be way ahead in cs, and thus gold. If he ever roams, punish him by pushing his mid tower hard.
Azir
Azir's only strength against cassiopeia is that he can zone her pretty well his soldiers. That being said, his cooldowns early game are pretty long, so if he mispositions his soldiers, be ready to go aggressive. Don't be afraid to trade with him, just remember to move out of the range of his soldiers when you are trading. You will significantly outscale him later in the game.
Lux
Lux is not too difficult to deal with. As long as you can dodge her binding, you should be fine in lane and for the majority of the game. The only problem is that her range will make it hard to harass her, so roam and farm your jungle whenever possible.
Ziggs
Akali
Akali is super easy to deal with pre-6. You should be able to easily outrange, ourharass, and out farm her. Be super aggressive pre-6 because you want to set her as far behind as possible during her weakest stage of the game. Once she hits 6, you will have to start playing more cautiously and closer to your tower. Invest in pink wards early on to get free kills on her when she engages on you. Drop the pink ward and miasma on her shroud and go to town. Unless you are substantially ahead, you may want to purchase some early magic resist. Buy a Negatron Cloak early on and upgrade it later into an Abyssal Scepter if you are having problems with her burst.
Brand
Playing against Brand early game is a skill matchup. If he lands his stun on you, hes going to put out the hurt. However, with the MS you get from your Q, you should be moving fast enough to dodge most of his skillshots, while still getting in some harass. You will heavily outscale him late game.
Veigar
Veigar should never be able to kill you during the laning phase unless you get really far behind. If you rush RoA and Rylai's crystal scepter you will be too tanky for him to one shot you. You MUST invest in Merc treads, as they shorten his stun enough to allow you to flash/ult/zhonya's before his full combo goes off. Late game stay away from him and be ready to Zhonya's if he does catch you out.
Ahri
Ahri is not hard to deal with pre-6. With the movement speed from your noxious blast, you should be able to easily dodge her skillshots when you go in to do some damage. You should be able to control the lane pre-6, afterwards play a bit safer. Buy T2 boots early to be able to dodge her skillshots. If she all ins you post-6, stay calm, and ult her in between her spirit rush casts when she will certainly be facing you. You should outscale her into the late game.
Zed
Zed is pretty easy to deal with, especially in the current meta. Take Exhaust against him, and laugh at his attempt to all in you. Pre-6 you wreck the lane, as his only reliable means of farming is with his Q. If he all ins you, just drop your Miasma at your feet, exhaust, and destroy him. Rush Zhonya's and Seraph's Embrace/RoA and his chance of killing you will disappear completely.
Yasuo
Yasuo is pretty easy to deal with pre-6 because of your Miasma. Yasuo players are notorious for all inning around level 2-3, so just have a point in miasma ready and drop it at your feet whenever they engage on you. This will allow you to get off at least 2-3 Twin Fangs while you retreat. Take Exhaust, invest in armor runes, harass him whenever he tries to CS, and avoid confrontation in your minion line, as he will just dash around, making it impossible for you to land your Q's. Buy an early Seraph's Embrace/RoA and Zhonya's Hourglass and you should be able to easily out duel him at all stages of the game.
Orianna
Orianna can be a pain in the butt. Her shield makes it hard for your DPS to stick to her. On top of that, her slow makes it hard to engage on to her after landing a Q. Finally, her teamfight potential is generally better than yours late game due simply to her utility. That being said, you should be able to out DPS her during most stages of the game unless you fall behind. During the laning phase, you will want to harass her whenever possible, but don't all in her if her Q+W combo is up. The good news is that her ult is easily flashable, making it possible to easily outplay her during post-6 allins.
Fizz
Fizz is easily manageable pre-6. Anyone who says that he counters Cassiopeia is dead wrong. You actually destroy him in lane before he gets his ult. If he uses his playful/trickster to harass you, drop your Miasma at your feet and wreck him. You win exchanges post-6 as well as long as you dodge/flash his ult and land your Noxious Blasts on him.
Katarina
Katarina is somewhat hard to play against. Her ability to Shunpo over your skillshots makes it really hard to harass her. On top of this, her gap closer and burst damage can easily ruin your day. However, because she is a melee champion, you should be able to completely control the lane pre-6. After this, ward up, push her under tower, and force her to lose cs or get harassed. Don't try to 1v1 her unless she is getting wrecked in lane, especially since Petrifying Gaze is really hard to land.
Karma
Karma's shield makes it hard for your damage to stick. On top of that, her snare makes you very vulnerable to ganks, and getting caught out late game in teamfights. In lane, try to keep the pressure on her, even if your damage isn't sticking to her. Push the lane and farm your jungle whenever possible, and you should easily outscale her into the late game.
Diana
Diana's early game against you is really weak because of her lack of range. However, her shield makes it hard to make your damage stick. After she hits 6, she becomes incredibly scary, as her all in hurts a lot. One option is to rush an abyssal scepter, which will mitigate a lot of her damage, while still allowing you to DPS her down quickly.
LeBlanc
LeBlanc is not as problematic as most people make her out to be (though with her burst and mobility she is still a pain). Most LB players assume that their DPS is going to be higher than yours, but I guess they haven't played against many Cassiopeia players because they are dead wrong. Your level 1-2 are much stronger than hers, use this to your advantage to zone her and control the lane. If she all ins you, dont run, turn around and fight. A good trick when LeBlanc players constantly W + Q harass you and then Distortion out is to drop miasma where she came from so that when she blinks back you can follow up with as many Qs and Es as you can. Invest in an early Negatron Cloak if you need the MR.
Anivia
Approaching Anivia is almost impossible as cassiopeia, as she has a stun and a slow. Her harass is stronger than yours early game if she lands her skills, and she can easily chunk you. On top of that she outranges you. Try to just turn the lane into a farm fest. Roam whenever possible as you should outscale her, but realize that she is going to push your lane to tower incredibly quickly.
Though you should be able to engage her if she misses stun. If you are better at cassiopeia than she is at anivia you should be fine.
Lulu
Lulu is the most infuriating and annoying champion to play against. She outranges you and has a low cooldown shield that essentially makes your harass useless. On top of this, her ult makes it impossible to burst her down. Avoid 1v1 engagements with her from the start, and simply push lane and roam.
Xerath
Hard during laning but if you can dodge his abilites you should be fine. It is hard to engage him as he can easily stun you.
Syndra
Syndra is easily Cassiopeia's hardest counter. She outranges, outharasses, and out CCs you in practically every way. She can burst you down before you DPS, and any attempts at following up a Noxious Blast with some Twin Fang's are always met with a stun and a lot of damage. Avoid direct confrontation with her throughout the game, and call for ganks. Late game you will outscale her because you have higher DPS.
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