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This build makes sense to me except of the Mana Potion. Why to buy Mana Potion instead of another Health Potion? The Mana Potion could be great for low-mana characters but for Karthus? His mana pool is so high that one Mana Potion makes almost no difference. But Health Potion might give him a lot of health (because he has quite low health at all).
But I like this build at all (except of that Mana Potion). Just one note: Archangel's Staff is not the giant of giants of AP.... Rabadon's Deathcap gives you much more and even if it doesn't stack, it gives you more. Overmore, if you buy Archangel's Staff, you have to wait a lot of time before it charges (at lease 12,5 minutes but probably about 15-20 minutes).
But I like this build at all (except of that Mana Potion). Just one note: Archangel's Staff is not the giant of giants of AP.... Rabadon's Deathcap gives you much more and even if it doesn't stack, it gives you more. Overmore, if you buy Archangel's Staff, you have to wait a lot of time before it charges (at lease 12,5 minutes but probably about 15-20 minutes).
Archangel and spell vamp are terrible for Karthus. Take an RoA instead and move the mejai's more up. Also you must start with boots in most games.
Lmao your ******ed bro, there is a RoA in that build and Archangel is amazing on karthus considering the amount of lay waste he casts. Some times boots are necessary though against champions like Brand or Orianna. Mejai's should be nice and early though. Right around when you gank.