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Cassiopeia Build Guides, Runes and Items

Cassiopeia The Serpent's Embrace

Find the best Cassiopeia build guides for League of Legends S14 Patch 14.5. The MOBAFire community works hard to keep their LoL builds and guides updated, and will help you craft the best Cassiopeia build for the S14 meta. Learn more about Cassiopeia's abilities, skins, or even ask your own questions to the community!

Season 14 Guides // Patch 14.5
9.8
521
Votes
28
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

💀 [ NEW SEASON 14] CASSIOPEIA - The POISON Queen of Midlane ☠ 💀

Guide by RezoneVerified updated March 7, 2024
  • In-depth
7.9
70
Votes
14
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Raen's Cassiopeia (°,,°) Tips & Build

Guide by Raen updated March 7, 2024
Season 14 Guides // Patch 14.4
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Snake build 🐍

Guide by Budgizee updated February 23, 2024
Season 14 Guides // Other Patches
8.1
6
Votes
0
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

[14.2] Mathematically Correct Cassiopeia

Guide by yomagest updated January 27, 2024
Season 14 Builds // Patch 14.5
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Tankyopeia

Build by WilsorBR updated March 7, 2024
Season 14 Builds // Other Patches
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Calamiteia

Build by WilsorBR updated February 16, 2024
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassio

Build by Guest updated January 26, 2024
Season 13 Guides
8.8
25
Votes
4
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

[13.1] Zethal's Cassio Guide | Latest Build + Advanced Tips

Guide by Zethal_Na updated November 10, 2023
  • In-depth
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

[13.19] Cassiopeia Support / The Powerful Sustaining Support

Guide by FlopQueenEra updated September 14, 2023
9.5
17
Votes
0
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

S13 - Challenger Cassiopeia Guide

Guide by Yurox updated May 31, 2023
  • In-depth
8.3
7
Votes
0
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Masters Cassiopeia Guide to Playing Snek!

Guide by Zeusman00 updated May 16, 2023
  • In-depth
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

[13.9] Master Cassiopeia battlemage queen. Tanky approach to cass

Guide by zuboun159 updated May 8, 2023
Season 13 Builds
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia Guide by Challenger 986 LP

Build by fuujiN1 updated September 15, 2023
7.5
6
Votes
1
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia Jesuscirraptor MID Heal and Shield Power

Build by Jesuscirraptor updated August 11, 2023
  • Off-Meta
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia Jesuscirraptor MID The Fast

Build by Jesuscirraptor updated August 9, 2023
  • Off-Meta
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

cassiopeia op oneshot

Build by Guest updated July 16, 2023
  • Off-Meta
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Queen Cobra Cass (Bot Lane CARRY)

Build by Faxual updated May 31, 2023
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

S13 Cassiopeia

Build by hughjanis99 updated January 13, 2023
Season 12 Guides
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

cassiopeia Build Guide Season 12 (low ELO)

Guide by Mvrshy updated August 13, 2022
  • In-depth
9.5
284
Votes
16
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Hyrav's Challenger Rank 1 Cassiopeia Guide

Guide by Hyrav updated August 2, 2022
  • In-depth
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Cassiopeia Build & Runes

If you're looking for the best rune build for Cassiopeia we've got you covered. Below you can find the best items and runes to build for Cassiopeia, as determined by calculations of thousands of Plat+ League of Legends games. If you are already familiar with how to play Cassiopeia this is a great resource to quickly get a good rune selection for Patch 14.5. However, if you are a new Cassiopeia player we highly recommend reading through some of the guides above to learn why this build is strong on Cassiopeia!

Our Stats Powered By LeagueOfGraphs.com LogoOpen In New Window
Patch 14.6: 28,146 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 51%

Win Rate 65% Pickrate

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune:
LoL Rune:
LoL Rune:
LoL Rune:

Sorcery
LoL Path: Sorcery
LoL Rune:
LoL Rune:

Second Best

Cassiopeia's 2nd Best Runes 51%

Win Rate 16% Pickrate

Sorcery
LoL Path: Sorcery
LoL Rune:
LoL Rune:
LoL Rune:
LoL Rune:

Precision
LoL Path: Precision
LoL Rune:
LoL Rune:

Third Best

Cassiopeia's 3rd Best Runes 49%

Win Rate 13% Pickrate

Precision
LoL Path: Precision
LoL Rune:
LoL Rune:
LoL Rune:
LoL Rune:

Resolve
LoL Path: Resolve
LoL Rune:
LoL Rune:

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 51%

Win Rate 74% Pickrate

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 51%

Win Rate 13% Pickrate

Flash Ghost

Third Best

Cassiopeia's 3rd Best Summoner Spells 48%

Win Rate 6% Pickrate

Flash Ignite

Cassiopeia's Starters

Cassiopeia's Best Starter Items 50%

Win Rate 79% Pickrate

  • 1
  • 2
  • 3

Cassiopeia's Core Items

Cassiopeia's Best Core Items 54%

Win Rate 19% Pickrate

  • 1
  • 2
  • 3

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 49%

Win Rate 57% Pickrate

  • 1
  • 2
  • 3
Our Stats Powered By LeagueOfGraphs.com LogoOpen In New Window
Patch 14.6: 28,146 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 53%

Win Rate 65% Pickrate

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune:
LoL Rune:
LoL Rune:
LoL Rune:

Sorcery
LoL Path: Sorcery
LoL Rune:
LoL Rune:

Second Best

Cassiopeia's 2nd Best Runes 54%

Win Rate 26% Pickrate

Sorcery
LoL Path: Sorcery
LoL Rune:
LoL Rune:
LoL Rune:
LoL Rune:

Precision
LoL Path: Precision
LoL Rune:
LoL Rune:

Third Best

Cassiopeia's 3rd Best Runes 58%

Win Rate 5% Pickrate

Precision
LoL Path: Precision
LoL Rune:
LoL Rune:
LoL Rune:
LoL Rune:

Resolve
LoL Path: Resolve
LoL Rune:
LoL Rune:

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 54%

Win Rate 84% Pickrate

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 52%

Win Rate 7% Pickrate

Flash Ghost

Third Best

Cassiopeia's 3rd Best Summoner Spells 57%

Win Rate 4% Pickrate

Flash Ignite

Cassiopeia's Starters

Cassiopeia's Best Starter Items 54%

Win Rate 73% Pickrate

  • 1
  • 2
  • 3

Cassiopeia's Core Items

Cassiopeia's Best Core Items 57%

Win Rate 14% Pickrate

  • 1
  • 2
  • 3

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 51%

Win Rate 44% Pickrate

  • 1
  • 2
  • 3
Our Stats Powered By LeagueOfGraphs.com LogoOpen In New Window
Patch 14.6: 28,146 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 47%

Win Rate 60% Pickrate

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune:
LoL Rune:
LoL Rune:
LoL Rune:

Sorcery
LoL Path: Sorcery
LoL Rune:
LoL Rune:

Second Best

Cassiopeia's 2nd Best Runes 53%

Win Rate 14% Pickrate

Precision
LoL Path: Precision
LoL Rune:
LoL Rune:
LoL Rune:
LoL Rune:

Inspiration
LoL Path: Inspiration
LoL Rune:
LoL Rune:

Third Best

Cassiopeia's 3rd Best Runes 55%

Win Rate 12% Pickrate

Precision
LoL Path: Precision
LoL Rune:
LoL Rune:
LoL Rune:
LoL Rune:

Resolve
LoL Path: Resolve
LoL Rune:
LoL Rune:

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 49%

Win Rate 50% Pickrate

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 50%

Win Rate 19% Pickrate

Flash Teleport

Third Best

Cassiopeia's 3rd Best Summoner Spells 47%

Win Rate 12% Pickrate

Exhaust Flash

Cassiopeia's Starters

Cassiopeia's Best Starter Items 50%

Win Rate 82% Pickrate

  • 1
  • 2
  • 3

Cassiopeia's Core Items

Cassiopeia's Best Core Items 49%

Win Rate 10% Pickrate

  • 1
  • 2
  • 3

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 51%

Win Rate 51% Pickrate

  • 1
  • 2
  • 3

Cassiopeia Counters

Learn Cassiopeia's counters and discover matchups where they have an advantage! When you're starting a game of League of Legends you should always keep in mind if you'll be at an advantage or disadvantage against your opponent, so you can know whether to bully them or play safe. You can find detailed breakdowns of each matchup on CounterStats, and you can also check out some Cassiopeia guides to see how to build and play against other champions you may find yourself up against!


This counter data is for Cassiopeia MIDDLE in Plat+ games. The percent shown is the enemy champion's counter rating against Cassiopeia. Counter rating is our own statistic that factors in counter kills, overall kills, early lead ratio, comeback ratio, and win percent to give the whole picture of that champion's effectiveness as a counter pick.

CR is Counter Rating, which is a combination of multiple counter factors. Counters shown are for Cassiopeia Cassiopeia MIDDLE

Cassiopeia Skins

Cassiopeia's Abilities

Questions About Cassiopeia

Ask

Latest Questions

Feeling difficult to deal damage to mages who build RoA, what should I do?

Situation: In the early-mid game, I built Morellonomicon, opponent built RoA. Problem: Feeling difficult to deal damage to opponents who build RoA. As they have higher effective health after building RoA, I feel like 'my abilities do not...

View (4) Answers

Which way is Katarina facing when she ults?

If you need the enemy to be facing you for the Cassiopoia ult to be a stun, then which way is Katarina facing while she is ulting?

View (2) Answers

Question on Cassiopeia

I want to main Cassiopeia mid to climb the ladder, but i'm far from learning anything about her besides some combos. Should I just focus on tear for the majority of early, or is it better to constantly harass my opponent? What match-ups do I...

View (2) Answers

Who should i choose?

???????????????????????? [b]Best Option[/b] ???????????????????????????????????????????? [color=#0080ff]Ahri , Cassiopeia , Diana , Ekko , Vladimir[/color]

View (3) Answers

Who is the most OP champion in the game?

I am wondering who is the most OP champion to play. I wanna see how well I can do.

View (23) Answers

What are some fun or brainless champions?

I have no idea who I should buy; any suggestions?

View (8) Answers

Was Cassiopeia recently buffed?

Title.

View (1) Answers

cassiopeia at bot lane

has anyone tried to play cassiopeia at bot lane instead of an adc? as i don't main her nor am i at a high level of play i don't know how vibiable it can become. basicly here are some thoughts: 1. as an adc cass is a sustained damaged - low...

View (4) Answers

Timing of a DoTs first "tick"

So I wanted to ask this because I couldn't find it on LoLWiki. I've been under the impression that with DoTs the first tick of damage is done on application making it so that reapplying it in rapid succession will redo the first tick of damage....

View (0) Answers

Lich bane Cass

So I've noticed that every time you use [[twin fang]] on Cass, you get an auto attack in between the .5 sec cooldowns. So i was wondering how she would fair with a [[lich bane]] as compared to other build options

View (2) Answers

Next AP Mid to learn and why?

Hey, so I can't really decide which champion to learn next after I have finished with Evelynn. I play AP Mid in a fixed 5vs5 team so I need champions who are valuable in organised competitive play. Champions I currently am able to play on a decent...

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