This is a Cho'Gath guide,i personally use this build and i fight and tank very well because of the damage and the defense that i have.Cho'Gath its a meelee tank that may do several damage in time.

For runes,i recommend physical damage seals,marks,gylphs and Quintessences(flat ones)fora headstart and for a better tanking.

For masteries i pick 4 points in ability power,3 for mana regen,and the rest for defense includin helt per level,healt regen and others.

For items i start with Meki Pendant for the very annoying mana problem and for start building Archangel's Staff which will give me more ability power empowering my Rupture and Feral Scream helping me make assists from kills by his combo.Aftter this i will continue with Rod of Ages for ressistance and more mana,Rylai's Crystal Scepter for more health and finishing with Warmog's Armor and Force of Nature for health regen,magic ressistance,and hp.

I first start with rupture for my infernal aggresive start,maximizzing it first,if you're not very accurate with these future positions you may try maximizing it last,maximizing Feral Scream first.

For summoner spells i take flash for escapes and high risk situations and hel for me and my team.

For a great teamwork use the Q-W combo for heav damage,slow and silence,then attack them along ith your teammate

Consider farmong minins with your ultimate because of the short cooldown,and the stacks that you receive after kiling them,receiving bonus health for a better tanking.