Hi,
Thanks for checking out this Elise build guide for Twisted Treeline. This is not a guide that you should follow explicitly each and every time as there are many different ways to play a champion. The main thing to take away from this guide is that Elise is squishy, yet her abilities do massive damage and don't require a full offense build for her to be effective. This build works very, very well for me and I use it every time I play with her. I appreciate any constructive criticism offered up but please do not downvote until you actually try the build out with her. Please read my explanations as well. Thanks.

Marks - Greater Mark of Insight x 9 Magic penetration is key for any mage and Elise is no exception.

Seals - Greater Seal of Resilience Because 3's typically consists of AD bruisers, armor is always good and these offer a great deal of survivability early game.

Glyphs - Greater Glyph of Focus The purpose of cd reduction is simply to get her spells back around a split second sooner to help finish off kills or make your escape.

Quintessence - Greater Quintessence of Potency Ability power is important for any mage and these quints really help with her early game damage. Speed quints are a viable replacement, however I wouldn't waste my time with them.

I'm going to keep this short and sweet. The points are mostly self-explanatory as to why you would choose them. There are a few questions from the defense tree so I'll go over them. Armor, health, damage reduction, and cool-down reduction. All of these make Elise a much bigger threat as she can stick around far longer than expected. I have gotten many kills and can 1v2 quite successfully because I take so much less damage and have that extra health.

Because you don't have any mana regen in your build, it is a great idea to start with boots and a Doran's Ring. Next it is very important to build more health for Elise and rush a Rylai's to slow opponents down so you can finish them off early game. Next, Lichbane offers extremely huge damage output and should be built asap.

Because you will be switching back and forth between human and spider form, this sinks very well with getting that extra damage in while in spider form. From here build more cdr, ability, power, armor or MR (depending on your opponents), and finish with a Blackfire Torch to melt that late game health away.

Ghost- Because of the new Twisted Treeline and Elise's ability to jump walls anyway, flash just doesn't mean as much. Ghost allows her to get away more efficiently or to stay on an fleeing opponent.

Ignite - This spell is a must in almost any situation. The only other option you should consider is exhaust, and that is only if your team already has 2 ignites and no exhaust utility. This is a team game after all.

Efficient farming is done best in Spider form. To farm quickly however, you start in human form, us her volatile spiderling ability (W), then switch to spider form and use your (W) again to take out minions by the droves. Just do this over and over and you can clear waves rather quickly with her.

Start off in human form if you can. Start with her W, then Q, then stun them. This is ideal because at this point, while they are stunned, you will switch to spider form and Q them, then W. At this point they should be close to death unless they are very tanky.

Another way to start is with your stun (E) then (W) then (Q), switch to spider form, (Q) then (W), use ignite, wait for your (Q) to come back up again, use it, then switch back to human form as your (Q) and (W) will be back up again.

Another way to open is in spider form and using your (E) to get onto your opponent. At this point, Q them, then switch to human form, (E) to stun, (W) then (Q), then back to spider form to finish them off or continue the cycle.

The idea here is to start in Human form, do as much damage as possible, use common sense from there as you switch back and forth from human to spider form and destroy your opponents.

Again, this isn't a guide to follow to the letter and no guide is. I haven't gone into a lot of extra detail about every little suggestion because you shouldn't need an explanation about why 1+1=2. Most people don't read the entire extent of a very indepth guide anyway. If you do have questions though, I'd be happy to explain things further to you. Just leave a question and I'll leave an answer.

Thanks.