Miss Fortune Build
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
I've played and tested this build 10 times it has not failed me yet, the only weakness is morde and tanks that stack MR early game. It optimizes MF early game instead of leaving her weak like AD does, it contributes to 3 abilities, the most used being let it rain and impure shots. If you feel like you need Madreds earlier switch it with guinsoo's. Also, when dealing with teams with a yi or another HIGH dps melee character i suggest dropping madreds or guinsoo and picking up thornmail it helps so much.
My skill order is the way that it is because "make it rain" allows miss fortune to harass early game amazingly well, also it lets her farm several times more quickly. Double up is a waste of mana early game as it does little dmg with an AP build but it does attribute better late game especially with guinsoo's attack damage. i suggest activating impure shots as often as you harass it is especially effective when the enemy champion is using a potion as it knocks off a bunch of the healing gained from the pot.
I suggest getting the lizard as fast as possible the slow and magic dmg plus impure shots and make it rain make it fairly easy to gank enemy champs especially melee as with Miss's passive movement speed buff it makes it easy to catch those run away champs.
I chose the summoner's spells ignite and exhaust simply because MF's passive is as effective as ghost. Also exhaust is the best protection from teemo and kog'maw. You can replace exhaust with ghost if you feel like you get hit too often for your passive to work.
I'm unsure if my skill order will work as i can't remember the rules for them, but i'm pretty sure everything up to level 8 will work. If you have any suggestions please post them.