Karma is a very powerful Support/DPS if you know how to build her and use her. First off, I would like to say is that Karma needs to be in group fights!!. You are the person who decides who lives and dies. Your shield can be a life saver if one of your team mates gets low or steps on a teemo shroom. Your ult shield combo i find is your main source of damage. Your Q(Heavenly wave) is uses to farm or heal your allies when combined with your ult. you can keep your teammates in lane for a long time with your heal. And finally your Spirit Bond is your main way of getting to a place fast with a team mate, or slowing down a enemy for a gank. Also it can be used to farm by attaching it to a team mate and running though minions.

Karma Pros Cons
Pros:
-Heals Team mates
-Shields Team mates
-Can do massive DPS late game
-She can make her whole team move faster with Spirit Bond

Cons:
-Very squishy early game
-Early game she runs out of mana very quickly
-Gets targeted quite often as she is a powerful support

Your runes are important for 1 reason. Early game you get the AP witch helps you and late game the Mana Regen will help allot. The speed also helps you catch up to your teammates and chase down enemys with low hp. being that you need speed to be effective cause your abilitys can only be used close range

My Masteries I like to go 9/0/21 with increased speed in Utility. This allows you to run quickly so you can aid your teammates without dieing.

My summoner spells I use are Teleport and Ghost. Teleport is very helpful to get to your teammates quickly to save them and Ghost is used to get away or get to the battle when your TP is on CD. You don't really need Exhaust because your Spirit Bond slows them down significantly.

The items i go with are to start off with the meki pendant. You can start off with dorans ring but i like to get started on my build as fast as I can. Then you want to get your Eleisa's Miracle. This is the new item, it gives you Regen for Hp and Mana. this is very important because you run out of mana quickly because you are constantly using spells. Late game if you find you are running out to quickly. Sell it and buy the chalice of harmony. Then you are on to your Boots. The Ionian boots of Lucidity are good for the CDR because her ult is dependent on your CDR. Start off with the Boots of speed, and then get to work on some CDR. The Kindlegem to start building Shurelya's Reverie This will give you some durability from the Hp it gives and and the Mana regen, also the 15% CDR. Then you will want to get your Ionian Boots of Lucidity. This will give you 39% CDR, you can throw in a Gylph that gives you about 1 per/lv, this will give you a evan 40%, but 39 is all you need really. Now you want to start on your rod of ages, start with the catalyst the protector and then on to the rod. after this you will be really needing your ap as your team depends on you to heal them and shield them from incoming damage. So now it is time to get your Rabidons Deathcap. After that you can work on the rylais crystal sceptor if you havent already dominate the enemy team.

Okay so Karma is the person who chases down the enemy with a team mate and then just DPS the hell out of them. So your main combos are to use Spirit Bond to slow them down, then you when you get close enough you will ult then use Soul Shield to do some massive damage and then Q to do some more. And the more health you loose the more powerful you become dont forget that.

Karma is one of the most efficent farmers in the game in my opinion. In order to farm very fast you need your 40% CDR and at least 60 Mana regen. so what you do is go in between the mage wave and the fighter wave and cast your Soul Shield combo (with ult) and then get in front of them and cast your Heavenly wave (IMPORTANT: only use the combo on your Q if you are healing it dose no extra damage) I would save your ult for the E combo dose way more damage. Another way to farm is to use Spirit Bond on a minon and then run through the enemy minons and then just Soul Shield combo to finish them off.

Laning with Karma is very easy once you get the hang of it, all you do is baslicy sit back and try to last hit but most often all you do it just push with Soul Shield (ult) combo. you can push a lane fast and gain loads of $$$ fast with this combo ( ult E, Q) or (W and hit all minons and then ult E) you will find most often that you will be a high level than the other team reason being that you are pushing them out of exp because they know that you can take there minons down pretty fast and they dont wana mess with you because karma is a *****!

Karma can also mid, but id rather duo lane I do not recomend Mid laning with Karma because she really relies on her team mates allot.