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12 desolation runes is too much
it's best if you get 9x Mark of Attack Damage and 3x Greater Quintessence of Desolation
you do not need Seal of potency, I would imagine you use it for void spikes, void spike are not really your main damage dealer skills, I see them as good sustain in the jungle, however if you evolve void spikes they will deal noticeable damage. So the ap runes will be a waste of slot. You need to expand, add more sections.