Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Annie is basically like any other caster. The way to go is to get lots of AP. She can become very powerful and is capable of killing several enemies at one time. This is one annie that opposing teams wont want to feed.
Very high AP and mana
Good heath and mana regen to go along with it
slow and very low regular damage
not that much magic penetration