Miss Fortune Build
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
NOT FOR FIRST TIME MISS FORTUNE USERS!!! ALSO, THIS IS NOT ONE OF THOSE BUILDS THAT MEAN YOU ARE UNKILLABLE. PLAY SMART!
I always use this build when I am going to be mid with Miss Fortune. If your not going mid, you should probably go AD, because in my experience, it's just simply too hard to farm enough minions for ability power when laning with a partner.
Early Game: Grab your Meki Pendant and health pots and when you get to the mid tower, stay there. Dont try to harass before the minions spawn, just hug the tower. Once minions appear, stay behind yours, and try to aim your Make It Rain ability to get both the enemys melee minions and caster minions. Try to make sure you also last hit, as this will not wipe them out... yet. =D
Mid Game:Once you get ~2k gold, you can blue pill and grab your Tear of the Goddess and your boots. Use your abilities as often as possible to really farm that tear and get the most out of it as possible. I myself wait until i have ~3.3-3.5k gold so I can also grab my Mejai Soulstealer as well and start ganking. If you are still soloing mid, you should be able to easily harass almost any champ you are laning against just with your Make It Rain ability.
Late Game:If you played smart, and you grabbed Mejais, you should have atleast 8-10 stacks by now. If not, I would recommend selling it to help you get your Lich Bane faster. I have never had to do this, but then again, I almost always play premade with some friends (I don't like pugging as I'm sure nobody does, too many feeders!!!) If you get Lich Bane (whether you sold soulstealer or not), and after you grab Archangels Staff, if the game goes on that long.. get Zhonyas. It will save your life in team fights and possibly allow you to clean up if some of your teammates have died but the enemy is low on health. I've never made it far enough to get past Zhonyas, but I'm sure Void Staff would have your enemies fleeing from you, as Make It Rain should do ~700-800 damage now just over 2 seconds, plus one attack from Lich Bane, then Impure Shots, auto-attack again, and unless they are tanky, they should be dead or close to it.
This is my first build, did my best with the description, I'm not really good at explaining things through text but I tried!