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1. Why do you have points in haste and burning embers, when you aren't using ignite and ghost?
2. Why are you using two secondary runes? I get a feeling that you would benefit a lot more from mana reg/5 yellows and magic pen reds where you get full bonuses rather than ~50% effectiveness.
http://www.mobafire.com/league-of-legends/build/rune-tips-what-secondary-and-primary-means-and-more-24255 is a great guide for more info on runes.
I personally wouldn't wanna get rid of my dodge yellows and flat health quints on Nasus though. However, I think I'm gonna try magic pen marks and a lichbane, and go for AP just to see what happens.