Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
My build for Vladimir.. ^^
I've scored Pentakill many times using this build, also many Quadras..
If you play Vladimir properly, there's nothing that can take you down.
Don't play too offensive at first levels. Play defensive untill level 7 or so, when your Transfussion gets low on cooldown.
At first levels, use most your transfussions on minions, for farming. Don't save them for champions because of the cooldown, it barely damages them. Use it for farming untill about level 3 Transfussion.
If there's a tank with much magic resist,
you can switch Warmog's Armorwith a Void Staff
And also you can switch Ignitewith Flashif you like, Ignite is for battles that you may not reach the one you fight (might die), and flash would be good for running away and chasing people down when you're sure you won't die.
Rate up if you like! ^_^