Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
1:Amazing Team Fight
1:AOE Slow and AOE Expunge Damage
3:Stealth (Considered the moving ward)
2:Usually First targeted
3:Vision Wards - Oracles end the stealth fun.
Reason for my Runes and items.
I always start with Dorans Blade and a hp potion to make me less squishy and its just a all around good item. I continue to grab 1-2 more to get 12% Life steal and the extra health at lower levels can keep you alive in the field and in battle. Now for boots. I like to take boots of speed 5. This being you should almost always be in combat being that your in stealth. These boots will allow you to position yourself in team fights. I cant stress how important it is to use spray and pray wisely to be able to hit all enemy targets with it will surely make your team win. *(Twitch is a crazy Team fight changer)*
Now Start working on Infinity Edge, for the 250% critical damage.
I like executioners calling for enemies who have natural healing. It can be used to cut healing by 50%
Enemies its good against.
Quite a bit of champions can be easily countered by this. Now you may think well isnt Ignite for that? Well ignite isnt always up now is it :] and with experience I have been able to 1v1 a tanked out Mundo with his ult on without a problem.
Zeal next for my item of choice, because crit chance and the movement speed and when its eventually turned to Phantom Dancer you will be critting like crazy with the complimentary Infinity Edge. And moving quick with boots of speed 5.
Now that you can attack super fast with beefy crit damage, I take WarMogs! YES WARMOG! having all that health will make people face palm! Through personal experience twitch can kill others way before hes even close to death with warmogs.
Turn your Zeal into Phantom dancer and watch your machine gun crit!
Now the last item is personal Choice being that there both great!
Black clever for the -Armor And 75 Damage to make your crits hit higher.
Or Last Whisper which is cheap great DPS cause it cuts armor by 40% which is ridiculous with any AD DPS.
My Choice of runes.
Now you may say never go all crit chance. Arp is better! I do agree with armor pen it is very very good. But at the start of any game, I would prefer to have the max crit chance runes you can get to land those early ganks. With Ignite - Exhaust and your ability to walk right up to your laner and unload a ignite exhaust combo with twitches poison and crits for 189-200 at lvl 1 you will be well on your way to getting first blood and many many more ganks around the map.
This has been my twitch guide try it out if you doubt my reasons for items and Runes. You will be amazed what you can do with this little rat guy
Thank you for your time and please rate if you like it :)