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Thank you for the constructive criticism and the vote :)
It's interesting to see an AD/Hybrid Poppy used for ranked play, opposed to the traditional AP Poppy. I'm all for breaking the mold, but I'm having a hard time buying that this build is superior to an AP build. Perhaps a little commentary on how you play this build compared to an AP-Poppy Assassin would help me understand how the AD and life leech add to her power.
Assuming you're doing a lot of chasing with Poppy, you might want to consider trading in some of the attack speed for damage or ability power. When chasing, you spend a moment catching up after each swing, so your attack speed is capped by that even if you have a high attack speed.
I also think you may have made a small rune error when making this guide ;) I think you meant to put your Greater Glyph of Magic Penetration as a Greater Glyph of Scaling Ability Power and your Greater Mark of Scaling Ability Power as a Greater Mark of Magic Penetration.
I look forward to seeing any updates on the guide.
Cheers,
PureKnickers