SKILL SEQUENCE:
For your skills, you should first unlock Tumble, then get Silver Bolts until the first time it doesn't let you level it up, at that time, unlock Condemn. After that, you should get your ultimate whenever you can. If you can't, get Silver Bolts whenever you can. If not, you should get Tumble whenever you can. The last skill you should get up is Condemn.

STRATEGY:
You should start with Boots of Speed and 3 health potions. Play carefully because this build is squishy (minions will melt you). Do not initiate fights, unless you are 100% sure you will get the kill. Personally, when I can get a kill, but die right after, I always go for it. Vayne gets really strong once she gets her first few main items, and after that she can get many kills without dieing, so getting 1 kill for 1 death is not a bad idea (but of course, try to get the kill without dieing if possible). Buy health potions whenever needed. Elixirs of Agility are recomended to use after you get your first Phantom Dancer. If your opponents have a lot of armor, or you don't have many armour piercing runes, your last item should be Last Whisper (instead of Youmuu's Ghostblade).

TIPS:
1. A good combo to use is normal attack, Tumble, then normal attack again. Tumble cancels the delay between attacks, therefore you can do one normal attack and one empowered attack really fast, after that, if you can, get the third hit to activate Silver Bolts.

2. Berserker Greaves, Vayne's passive, ultimate, and in late game, the two Phantom Dancers allow Vayne to move really fast, so if your opponent is running away with low HP, you can chase them down and secure the kill.

3. You should get good at using Condemn, as the stun from it is very useful. You get more opportunity to use Condemn in Twisted Tree Line, and the least in Crystal Scar (Dominion map)

4. Get the third hit in for Silver Bolts whenever you can.

5. Get every possible last hit on a minion.

6. To escape a death, simply use Condemn, then Tumble in the opposite direction. Use flash when necessary.

7. When you are with your team, it is good to use your ultimate and dash to get to the enemy and exhaust them, so that the team can get the kill.