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Playing as Vladimir, I find it easy to 1) Harrass and 2) Stay high health. I find that going defensive masteries instead of utility better seeing Ardor, Veteran scars, Tenacity etc are much better than slight cooldowns, exp gain and gold earned. Maxing Sanguine Pool last makes you REALLY REALLY vulnerable, so it should be maxed 2nd, after transfusion (or Tides of blood, seeing that rushing a spellvamp item makes it much easier to go for annoying damage build). For me, rushing Rabbi's Deathcap is a MUST, either after some tanky AP item like Rylai Scepter or something like Hextech revolver/WotA.
Your playstyle is almost confirmed different, and your escape plan is really unreliable. This makes you easy killer in mid game, but you die much faster and cannot pose as a good off-tank AP spellcaster (that most vlads are).
Hope it helps