Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
twitch is a great mid character. u will probably get a lot of kills and money when items are the key to this build.
twitch doesnt have many combos but one is ambush then attack from behind them if they run away debilitating poison and then kill them with expunge.
at higher levels twitch is an amazing pusher but dont draw any attention u can kill the turret with 1 round of minions.