Not Updated For Current Season
Always chose Boots and 3 Hp to start. Buy FAST and run to your lane and hide next to where you think your first set of melee minions will stop. Wait until your opponents show themselves to chose your first skill. Some times i will get Toxic Shot before Blinding Dart depending on who my opponent(s) are (ranged, mele, Ap, or Ad).
If they are aggressive ranged Ap or Ad you should play it safe (keep you distance, go invisible, hide/use the grass) until you get to level 6. The most important early game skill to master is getting last hits on minions (Building your items is ESSENTIAL).