Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Vayne is a new ranged character capable of doing alot of damage in a short period, and if used correctly can be a very effective carry for your team. I personally have gone 21/7 with this build. I plan to update it as I go in the future.
Pros / Cons
* amazing damage
*every 3 shots deals 8% of max health as damage
*tumble helps avoid skill shots, such a kog maw's living artillary.
*impale can be both a defensive and offensive ability
*Cant start team fights
*If she can't kill them fast enough tanks can be an issue because of her low health.
Play smart, Vayne isn't someone like who can take a bullet, ill cover him in another guide. Use Vayne the way she's meant to be used. As a DPS. Vayne needs to wait till someone else starts a fight and swoop in for mass damage. Positioning for the is very important, not only because of the stun but when you hit terrain it basicly does double damage. And can be used to help a fleeing teammate if needed.