Well I'm pretty sure everyone knows who Twisted Fate is. He is the guy with the pubes on his chest. He has his Gold Card which is pure HAX. Im going to give you an insight to the build that I use. Obviously, since i use it, it works.

So let's get started.

I chose Attack Speed runes because it really helps with the last hitting and harassing. The armor pen of course helps with killing off tanks especially after you get your Sword of the Divine.

I run 21/0/9 you can do whatever you want here it's all up to you.

You are going to really love sword of the divine and madreds bloodrazor. They are amazing. You hit so fast that you can solo a huge minion wave faster than AP TF.

So at the beginning Stack dorans. the hp and lifesteal will really help. Than get SotD and rush Madreds. Then your gonna probably be targeted a lot so have fun with that. When you get the moo lah grab a BF sword < its your best friend sword so DO IT. Then make yourself a blood thirster
so you can heal yourself. If you haven't already won and you have a buttload of cash spend it on another Best Friend sword and make yourself an infinity edge. And if the game last even longer than that your doing something wrong. LOL. Well anyways since your going to be targeted and everyone's builds are almost complete get a Frozen mallet. The HP boost will help amazingly and the slow will help you from losing your target since TF runs like a freakin amputee.

Grab Flash definitely.

The last summoner spell is up to you.

I run ghost or teleport. Teleport because you dont wanna bust out your ult every time right? so use this for the laning phase and if your too tired to walk somewhere.

Ghost is amazing for chases. not too great for running away since your still gonna run like you have a screw in your leg.

Don't suck. <--- Most important rule EVER. dont forget it. honestly. A lot of people choose to break this rule.

Other than that, help with ganks.
and learn how to save people or they will call you Twisted NOOOOOOB.

Good luck