Hi, this is my third guide, so don't be angry!!

Greater Mark of Strength 9

Greater Seal of Furor 9

Greater Glyph of Alacrity 9

Greater Quintessence of Malice 3

I think this runes is best for Vayne!!

MY masteries is 27/0/3.
You can make you own masteries, because you are big boy or girls.

Infinity Edge-Effects +80 attack damage
+25% critical strike chance
Passive Unique: +50% critical strike damage
Menu Attack > Critical Strike
Attack > Damage
Item cost 3830g (375g)
Sell value 2681g
Phantom Dancer-Effects +55% attack speed
+30% critical strike chance
+12% movement speed
Menu Attack > Attack Speed
Attack > Critical Strike
Movement
Item cost 2845g (400g)
Sell value 2026g
The Bloodthirster-Tier Advanced
Effects +60 attack damage
+12% life steal
Passive Gain +1 attack damage and +0.2% life steal per kill (maximum +40 attack damage and +8% life steal). Half of the bonuses are lost upon death.
Menu Attack > Damage
Attack > Life Steal
Item cost 3000g (900g)
Sell value 2100g

Tumble - Vayne tumbles, maneuvering to carefully place her next shot. Her next attack deals bonus damage.
Vayne tumbles a short distance and her next basic attack within 6 seconds deals bonus physical damage.

The bonus is equal to 30/35/40/45/50% of her total Attack Damage.
Cost
40 Mana
Range
300
Silver Bolts - Vayne tips her bolts with a rare metal, toxic to evil things. The third consecutive attack or ability against the same target deals a percentage of the target's maximum Health as bonus true damage. (Max: 200 damage vs. Monsters)
Vayne tips her bolts with a rare metal, toxic to evil things. The third consecutive attack or ability against the same target deals an additional 20/30/40/50/60 plus 4/5/6/7/8% of the target's maximum Health as true damage. (Max: 200 damage vs. Monsters)
Cost
Passive
Range
750
Condemn - Vayne draws a heavy crossbow from her back, and fires a huge bolt at her target, dealing damage and knocking them back. If they collide with terrain, they are impaled, dealing bonus damage and stunning them.
Vayne fires a huge bolt, dealing 45/80/115/150/185 (+) physical damage and knocking her target back.

If they collide with terrain they take 45/80/115/150/185 (+) additional physical damage and will be stunned for 1.5 seconds.
Cost
90 Mana
Range
575
Final Hour - Readying herself for an epic confrontation, Vayne gains increased Attack Damage, stealth during Tumble, and triple the bonus Movement Speed from Night Hunter.
For 8/10/12 seconds Vayne gains 25/40/55 Bonus Attack Damage, Tumbling grants Vayne stealth for 1 second, and the bonus Movement Speed from Night Hunter is tripled.
Cost
80 Mana
Range
0
Night Hunter - Vayne ruthlessly hunts evil-doers. She gains 30 Movement Speed when moving toward nearby enemy champions.

Flash-Teleports your champion a short distance toward your cursor's location
Ignite- Ignites an enemy unit, dealing (50 + 20 × level) true damage over time to a single target and reduces the health regeneration and the healing effects received by 50%.

Vayne is strong in bot or top lane! So you eill own them! GL&HF