Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Vayne is an squishy champion, her health is low and it's easy to kill her, so you always have to be prepare!
Summary, Tips and How to Play
Vayne is an solo champion, she's not for group fight.
In a group fight, you could hide in a nearest brushes and help your teammates kill one by one. And remember you always have to pick the lowest health champion to kill, to get in a group fight without any notices, use FINAL HOUR and then use TUMBLE to be invisible, after that start use CONDEMN to push the enemy to the nearest wall then you could kill that champion in tik tok.
When you look on the map, if you saw an enemy alone while the other enemies at other places far away you could solo that champion by using this skill in order:
After that keep chasing and shooting when the enemy almost died, use tumble one more time and shoot for final kill.