Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Probably,u will go at mid,on mid,try to harass minions and get the enemy champion's health on about a 600 HP,then(then u probably will more than lvl 6) cast TRANSFUSION,cast POOL so the enemy can't escape,cast IGNITE followed by another TRANSFUSION if he's not dead,take GHOST and dive the turret,when u kill him,take POOL and go to nearest grass and recall,if there are more enemies than one cast first HEMOPLAGUE(u must catch'em all),then throw POOL and go in the battle,when the POOL ends cast TIDES OF BLOOD,then throw TRANSFUSION on the enemy who has the lowest HP,that should be enough. :D
Creeping / Jungling
If there's a lot of minions,cast POOL to weak them,then cast TIDES OF BLOOD followed by TRANSFUSIONS,same tactics in junglig,in jungle u first cast TRANSFUSION on the primary mob(biggest wraith,redl izard,blue golem,...).
U can combine POOL in team fights because POOl slows,that will help ranged carryes that they kill faster...
At the end,u will have more AP and HP because of Vladimir s passive,this is my first build,i know it sucks,good luck to all