Hi, I'm IPeePeeOnYou. In this guide, you will learn how to effectively play and build Warwick. I will be using some terms that you might not understand. I will put the terms and their meanings below.

CS=Creep score, a term that originated from Dota 2. It means how many minion kills you have. For ex. 20 mins = 160 CS
AD=Attack Damage
AP=Ability Power
Baron=Baron Nashor
BD=Backdoor,To capture a capture point, typically the middle one, which is close to the enemy fountain and surrounded by two other enemy capture points
MR=Magic Resistance
Blue/Red=Blue Buff/ Red Buff
CDR=Cooldown Reduction
DPS=Damage Per Second
Bruiser=A tanky champion that usually goes top and has DPS

Marks:
In my opinion, Attack Penetration marks are the best for Warwick. It allows him to just rip through the oppositions armor dealing massive chunks of damage when combined with his W.
A okay substitute to Attack Penetration marks are AD marks, but they are not the ideal choice.

Seals:
For seals, I get Armor seals because Warwick needs to be tanky, and basically the only good substitute is Health seals, and those are useless when you don't have armor. Also, top lane is usually a AD bruiser so it will help with getting CS and harassing your opponent.

Glyphs:
I get Magic Resistance because if you win your lane, you should go gank mid often and mid is 95% a AP carry. Also, MR helps late game when the enemy mid get stronger. It could also help during laning if your against a champion that does magic damage such as Malphite or Diana.

Quintessences:
I get Magic Penetration quintessences because 1/3 of your damage will be magic, and even though your ultimate stacks off of AD, it does magic damage. Your Q also does magic damage. Some good substitutes are Armor or MR quintessences if you want to be more tanky.

These masteries are pretty obvious.

Offense Masteries:
These are pretty obvious, you get them for additional damage for minions, making it easier to CS and you want the extra 5 AD and AP whenever you use ignite. Attack Speed and Armor Penetration are good for Warwick Because of his W and Armor Penetration because 2/3 of his damage is AD.

Defensive Masteries:
I'm not going to go into these masteries that much, because they're the common tank masteries. Why you take these masteries is because it reduces some damage from minions and other things, and it makes you pretty tanky in general.