Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
This is a quick, very basic outline for Quinn, the Helicarrier. I'll add more later if I feel like it :P. Enjoy! :D
Trinity Force lets you semi-burst, and Essence Reaver gives you le manas so you can keep on roaming. The CDR also allows you to keep kicking people in the face. :)
Rapid Firecannon works naturally with your mobility and roam, and the extra range gives you the edge when flying head first into an assassination.
Thunderlord's Decree for max damage during your combo and CDR so you can keep kicking people in the face. :)
The most effectively use this build, you rely on your passive and the synergy with Trinity Force to secure ganks.
Typically, when going for a gank, you fly in, AA, Vault (E), AA, Blinding Assault (Q), AA. By this point, they're probably dead. If not, the CDR should refresh your Vault enough for another Vault(E), AA. If that doesn't work, start running cuz you ded xD
You're super squishy so watch out for hard CC's and be careful with the timing of your ganks.