Cait got your tounge
Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
At the time of this writing I am on lvl 21, so I only have about 80% of the masteries and runes; however, it still works for me.
So far the only issue is defense, but the Bloodthirster does help. This is still a work in progress but the majority of items are working for me. For now I've placed this as ADC, but I'm kind of thinking it may be better as an assassin type.