When in lane you are likely to get first blood if you play it smart. But afterwards be careful when you come back as you will most likely only have a tear and or a dagger while your opponent may have more tankiness or more damage than you. Try to rush your manamune quickly to stack it fast since your don't have the lowest of cool downs.

With this build you will have extreme damage so don't be afraid to to jump on a dps even when they are not isolated you can kill them very easily if you use a basic combo. DO NOT ult into a fight save it for after your jump if you don't plan on jumping right out or if you know your gonna get cc'd because since your glass cannon you will need your ult to be safe until you can kill again. Bottom line do not ult before your inside their team.