Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
So I was downstairs doing dishes when a thought hit me, Twitch has stupid far range and goes crazy nuts with crit damage. Why not do it with Kog'Maw king of range? So I did, and the results were better then I could have hoped for.
Start off with a Brawlers Gloves and a health pot or two, work your way up from there, if you get fed make the glove a Zeal if not Avarice blade. If you made it an Avarice get a Zeal then upgrade the Avarice to Youmuu's. (Buy boots here, I went with Berserkers greaves for giggles and they where quite useful early/mid game, I sold them end game since I didn't need the all the AS so I dropped it and just used my phantom dancers for speed). Upgrade your Zeal to a Phantom Dancer, and then buy another Zeal and upgrade that to a Phantom, Then buy an Inf edge, after that sell your boots get a Bloodthirster and roll face. You should be able to ace half a team or the entire team from the forest with your W up. Grab Lizard when its up and go nuts.
Skill order was
R>W>Q>E W being your nuke, Q for the armor pen. 50% armor pen with this crit damage is very nice.
Crit Damage because this build focuses around crit
Ghost and Flash to get away or get into range since we skill up the slow last. Though if you like other Spells use them, these are what I use though