Runes are listed. Pick any runes you like according to your desire to go more tanky or more DPS.

In both options masteries are the same.

Hey, this is Nasus guide. Not much words. No need to explain it by typing long long text. If you understand it, you understand it. Cpt. Obvious, i am. - Yoda

Don't be a douche, help your team, and don't be afraid to ask for help. If they don't help you, shout at them.

Try to lasthit creeps with Q, so you get more damage in the middle/end of game.

If you play careful and your team is good, no cons there are. Pros? If everything goes according to keikaku (keikaku means plan) then you become Anal Violator, just like i taught you.

Look up in intro. Good luck, don't rape people.