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Recommended Items
Spells:
Ignite
Flash
Items
Ability Order
Mortal Will (PASSIVE)
Pantheon Passive Ability
Introduction
For Runes, I usually run a fairly typical page of Flat Armor Seals, Scaling MR Glyphs, and Flat AD Marks and Quints. If I'm fighting a tankier opponent, I'll go Armor Pen Marks and keep the AD Quints, and if you're fighting an enemy who deals heavy magic damage early, Swap the scaling MR for Flat.
For Masteries, we invest rather heavily in Offense to capitalize on Pantheons incredible burst damage, and pick up some sustain from Defense and Utility, both HP5 and MP5 respectively. The summoner spell CDR from utility is useful for having flash up more often to make plays or escape ganks.
For Items, you'll want to focus rather heavily on AD and Armor Pen, with just enough tank to get you through fights. Normally, you'll start with either a Dorans Blade and Health Potion, or a Long Sword and 3 Potions. Crystalline Flask is acceptable for lanes you expect to be very sustain centric and Boots of Speed is more for lanes where your opponent is very mobile and you need to keep up. Since Season 4 started, I've considered Ravenous Hydra a very important pickup on Panth, as it lets him push easily and farm like a madman, while giving him excellent sustain from the lifesteal and burst from the AD and Active. Never forget about Hydras active, as it can be devastating when woven into your combo. Typically, you'll get an early Brutalizer followed by boots, Mercury Treads for heavy CC teams, Ninja Tabi if they're very AA heavy, and Boots of Lucidity if you don't need anything else, since Pantheon is very cast heavy.
Generally, you want to pick up Spear Shot at level 1, so you can poke and zone your lane opponent, but if you feel that the champion you're fighting will try and fight you off the bat, Heartseeker Strike can shred their hp bar like no tomorrow at level 1, so long as you don't let it get interrupted. Personally, as for skills to max, I prefer to max Heartseeker first, for its heavy damage output and potent AoE, but if against an opponent who wont stay in range long enough or who will constantly interrupt HSS, max your Q to harass and trade instead of going for the all in HP bar deletion that Pantheon's E is capable of. Obviously you put points in Grand Skyfall whenever possible, because while its useless in combat 99 percent of the time, its incredible for ganking and teamfigthing, or escaping if used right.
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